CALL FOR PAPERS Regulation of Lipid Metabolism and of Insulin Sensitivity by PPARs Skeletal muscle glycogen synthase subcellular localization: effects of insulin and PPAR- agonist (K-111) administration in rhesus monkeys
نویسندگان
چکیده
Heidi K. Ortmeyer, Yohannes Adall, Karina R. Marciani, Andreas Katsiaras, Alice S. Ryan, Noni L. Bodkin, and Barbara C. Hansen Obesity and Diabetes Research Center, Department of Physiology, School of Medicine, University of Maryland; and Geriatric Research, Education and Clinical Center, Baltimore Veterans Affairs Health Care Center, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland
منابع مشابه
Conjugated linoleic acid supplementation enhances insulin sensitivity and peroxisome proliferator-activated receptor gamma and glucose transporter type 4 protein expression in the skeletal muscles of rats during endurance exercise
Objective(s):This study examined whether conjugated linoleic acid (CLA) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 4 (GLUT-4) protein expressions in the skeletal muscles of rats during endurance exercise. Materials and Methods:Sprague-Dawley male rats were randomly divided into HS (high-fat diet (HFD) s...
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.............................................................................................................................. 4 INTRODUCTION ...................................................................................................................... 6 Energy metabolism in skeletal muscle ................................................................................... 6 Dynamics of...
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Agonists targeting the nuclear receptor peroxisome proliferator-activated receptors (PPAR)-delta may be potential therapeutic agents for insulin-resistant related conditions, as they may be able to stimulate fatty acid (FA) oxidation and attenuate the accumulation of harmful lipid species in skeletal muscle. Several reports have demonstrated that PPAR-delta agonists improve whole body insulin s...
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Abnormalities in fatty acid (FA) metabolism underlie the development of insulin resistance and alterations in glucose metabolism, features characteristic of the metabolic syndrome and type 2 diabetes that can result in an increased risk of cardiovascular disease. We present pharmacodynamic effects of AZ 242, a novel peroxisome proliferator activated receptor (PPAR) / agonist. AZ 242 dose-depend...
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